The prospects of ferroptosis in the pathogenesis of liver disease / 药学学报
Acta Pharmaceutica Sinica
; (12): 1783-1790, 2017.
Article
em Zh
| WPRIM
| ID: wpr-779790
Biblioteca responsável:
WPRO
ABSTRACT
Ferroptosis is a novel type of cell death which induced by iron-dependent lipid peroxidation accumulation. This type of cell death is significantly different from other cell death in terms of morphology, genetics and biochemistry. It has been reported that ferroptosis is involved in a variety of human diseases, particularly in liver diseases. Therefore, screening and studying of inhibitors or activators of ferroptosis may provide novel strategies for prevention and treatment of liver diseases. This review provides the biological characteristics and regulatory signaling pathways of ferroptosis, as well as the relationship between ferroptosis and liver diseases, which will contribute to new insight into the pathogenesis of liver diseases.
Texto completo:
1
Índice:
WPRIM
Tipo de estudo:
Etiology_studies
Idioma:
Zh
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2017
Tipo de documento:
Article