Evaluation of fractional flow in patients with intracranial atherosclerotic stenosis / 国际脑血管病杂志

ABSTRACT

Traditionally, the determination of cerebral vascular stenosis depends on the measurement of the degree of morphological stenosis, but it lacks the understanding and evaluation of hemodynamics. At present, the degree of morphological stenosis is still a clinical indication for interventional therapy. Non-invasive brain functional assessment cannot accurately locate the specific ischemic area corresponding to the stenotic lesion. Its spatial resolution to vascular lesions is poor, and it is not possible to assist decisions in real time during interventional therapy. The theory of fractional flow reserve (FFR) of coronary stenosis and pressure guidewire technology has been applied to the evaluation of coronary function and to guide the practice of interventional therapy for many years. With the need for screening for high-risk patients with intracranial vascular stenosis and hemodynamic dysfunction, the evaluation of fractional flow in the interventional treatment of cerebral vascular stenosis is increasingly significant. The safety and feasibility of the use of pressure guidewires in intracranial arteries have been confirmed by some studies. Evaluation of fractional flow has broad application prospects in both acute and chronic ischemic cerebrovascular diseases. This article reviews the application of fractional flow evaluation in patients with intracranial atherosclerotic stenosis.