Clinical and genetic analysis of a patient with Hb Ottawa in conjunction with β-thalassemia / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 1130-1132, 2019.
Article
em Zh
| WPRIM
| ID: wpr-800871
Biblioteca responsável:
WPRO
ABSTRACT
Objective@#To analyze the hematological characteristics of a patient with Hb Ottawa in conjunction with β-thalassemia.@*Methods@#Peripheral blood samples from the proband and her parents were collected and subjected to red blood cell analysis and hemoglobin electrophoresis. Genotypes of α- and β-globin genes were also analyzed.@*Results@#The proband and her mother were both heterozygotes for Hb Ottawa and β-thalassemia variant IVS II-654, and presented with typical β-thalassemia trait featuring hypochromic microcytic anemia. An abnormal hemoglobin band was detected upon electrophoresis.@*Conclusion@#Co-existence of Hb Ottawa and β-thalassemia may not aggravate the phenotype.
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Índice:
WPRIM
Idioma:
Zh
Revista:
Chinese Journal of Medical Genetics
Ano de publicação:
2019
Tipo de documento:
Article