Progress in developing Norovirus vaccines based on virus-like particles / 中华微生物学和免疫学杂志

ABSTRACT

Human norovirus (NoV) is the major cause of human acute non-bacterial gastroenteritis worldwide. The development of NoV vaccines is limited by the inability to culture cells in vitro and the lack of small animal models. Thus, traditional methods used to prepare live attenuated vaccines are not suitable for preparing NoV vaccines. Subunit vaccines against NoV infection, especially virus-like particle (VLP)-based vaccines, have outstanding advantages in the research and development of NoV vaccines. In this review, we focused on reviewing recent advances in the fields of NoV VLP-based vaccines and the development of NoV VLP-based vaccines using different expression systems as well as identifying the research direction for NoV VLP-based vaccines.