Expression and significance of STAT6 in solitary fibrous tumor / 中华病理学杂志
Chinese Journal of Pathology
; (12): 235-239, 2017.
Article
em Zh
| WPRIM
| ID: wpr-808524
Biblioteca responsável:
WPRO
ABSTRACT
Objective@#To study the clinicopathologic features, the differential diagnosis and the expression of STAT6 in solitary fibrous tumor (SFT).@*Methods@#Eighty cases of SFT were evaluated. The expression of STAT6, CD34, CD99 and bcl-2 protein was studied in these cases and in other groups of soft tissue tumors by immunohistochemical EnVision method. The results were analyzed and relevant literature were reviewed.@*Results@#The expression rate of STAT6 in SFT was 97.5% (78/80) and that in other soft tissue tumors was 3.3% (3/90). The difference was significant (P<0.05). The expression rates of CD34, CD99 and bcl-2 were 88.8% (71/80), 76.3% (61/80) and 75.0% (60/80) in SFT, respectively, which were significantly different from STAT6 expression rate (P<0.05).@*Conclusions@#The expression of STAT6 in SFT has high sensitivity (97.5%) and specificity (96.7%). The expression of STAT6 in SFT is higher than that of CD34, CD99 and bcl-2. STAT6 may be a useful marker for clinical diagnosis of SFT.
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WPRIM
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Zh
Revista:
Chinese Journal of Pathology
Ano de publicação:
2017
Tipo de documento:
Article