Understanding the Molecular Mechanisms of Asthma through Transcriptomics
Allergy, Asthma & Immunology Research
; : 399-411, 2020.
Article
em En
| WPRIM
| ID: wpr-811070
Biblioteca responsável:
WPRO
ABSTRACT
The transcriptome represents the complete set of RNA transcripts that are produced by the genome under a specific circumstance or in a specific cell. High-throughput methods, including microarray and bulk RNA sequencing, as well as recent advances in biostatistics based on machine learning approaches provides a quick and effective way of identifying novel genes and pathways related to asthma, which is a heterogeneous disease with diverse pathophysiological mechanisms. In this manuscript, we briefly review how to analyze transcriptome data and then provide a summary of recent transcriptome studies focusing on asthma pathogenesis and asthma drug responses. Studies reviewed here are classified into 2 classes based on the tissues utilized: blood and airway cells.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Asma
/
RNA
/
Bioestatística
/
Genoma
/
Análise de Sequência de RNA
/
Transcriptoma
/
Aprendizado de Máquina
/
Genética
Idioma:
En
Revista:
Allergy, Asthma & Immunology Research
Ano de publicação:
2020
Tipo de documento:
Article