Successful Treatment of a Korean Infant with Giant Cell Hepatitis with Autoimmune Hemolytic Anemia Using Rituximab / 대한소아소화기영양학회지
Pediatric Gastroenterology, Hepatology & Nutrition
; : 180-187, 2020.
Article
em En
| WPRIM
| ID: wpr-811412
Biblioteca responsável:
WPRO
ABSTRACT
Giant cell hepatitis with autoimmune hemolytic anemia (AHA) is a rare disease of infancy characterized by the presence of both Coombs-positive hemolytic anemia and progressive liver disease with giant cell transformation of hepatocytes. Here, we report a case involving a seven-month-old male infant who presented with AHA followed by cholestatic hepatitis. The clinical features included jaundice, pallor, and red urine. Physical examination showed generalized icterus and splenomegaly. The laboratory findings suggested warm-type AHA with cholestatic hepatitis. Liver biopsy revealed giant cell transformation of hepatocytes and moderate lobular inflammation. The patient was successfully treated with four doses of rituximab. Early relapse of hemolytic anemia and hepatitis was observed, which prompted the use of an additional salvage dose of rituximab. He is currently in clinical remission.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Palidez
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Exame Físico
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Recidiva
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Esplenomegalia
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Biópsia
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Células Gigantes
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Hepatócitos
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Doenças Raras
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Rituximab
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Hepatite
Limite:
Humans
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Infant
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Male
Idioma:
En
Revista:
Pediatric Gastroenterology, Hepatology & Nutrition
Ano de publicação:
2020
Tipo de documento:
Article