Effect of a Gluten Free Diet on Hepatitis B Surface Antibody Concentration in Previously Immunized Pediatric Celiac Patients / 대한소아소화기영양학회지
Pediatric Gastroenterology, Hepatology & Nutrition
; : 132-136, 2020.
Article
em En
| WPRIM
| ID: wpr-811418
Biblioteca responsável:
WPRO
ABSTRACT
PURPOSE:
To evaluate the effect of gluten-free diet (GFD) on hepatitis B surface antibody (HBsAb) concentrations among previously immunized pediatric celiac disease (CD) subjects.METHODS:
We retrospectively evaluated pediatric CD subjects in serological remission who were previously immunized for hepatitis B virus as infants. The temporal relationship between HBsAb concentration, the amount of time on a GFD, and age were evaluated.RESULTS:
Overall, 373 CD subjects were analyzed 156 with HBsAb sampled prior to GFD initiation and 217 after initiation of a GFD and in serological remission. Median age at HBsAb concentration measurement for those before and after GFD initiation was 5.3 years (interquartile range [IQR], 3.1–9.2 years) and 7.6 years (IQR, 5.4–10.9 years), respectively (p<0.001). There was no sex difference between the groups. The median time of HBsAb measurement was 2 months (IQR, 0–5.7 months) before and 12.8 months (IQR, 5.3–30.3 months) after initiation of GFD. The HBsAb concentration was low in 79 (50.6%) and 121 (55.7%) subjects before and after GFD initiation, respectively (p=0.350). Age was inversely associated with low HBsAb concentrations. Neither being on a GFD nor sex was associated with low HBsAb concentrations.CONCLUSION:
Adherence to a GFD does not affect HBsAb concentration in children with CD. Age is inversely associated with HBsAb concentration.Palavras-chave
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Índice:
WPRIM
Assunto principal:
Doença Celíaca
/
Vírus da Hepatite B
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Estudos Retrospectivos
/
Imunização
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Caracteres Sexuais
/
Dieta Livre de Glúten
/
Glutens
/
Hepatite
/
Hepatite B
/
Anticorpos
Tipo de estudo:
Observational_studies
Limite:
Child
/
Humans
/
Infant
Idioma:
En
Revista:
Pediatric Gastroenterology, Hepatology & Nutrition
Ano de publicação:
2020
Tipo de documento:
Article