Atractylodes lancea rhizome water extract reduces triptolide-induced toxicity and enhances anti-inflammatory effects / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 905-911, 2017.
Article
em En
| WPRIM
| ID: wpr-812042
Biblioteca responsável:
WPRO
ABSTRACT
The present study was designed to explore the influence of water extracts of Atractylodes lancea rhizomes on the toxicity and anti-inflammatory effects of triptolide (TP). A water extract was prepared from A. lancea rhizomes and co-administered with TP in C57BL/6 mice. The toxicity was assayed by determining serum biochemical parameters and visceral indexes and by liver histopathological analysis. The hepatic CYP3A expression levels were detected using Western blotting and RT-PCR methods. The data showed that the water extract of A. lancea rhizomes reduced triptolide-induced toxicity, probably by inducing the hepatic expression of CYP3A. The anti-inflammatory effects of TP were evaluated in mice using a xylene-induced ear edema test. By comparing ear edema inhibition rates, we found that the water extract could also increase the anti-inflammatory effects of TP. In conclusion, our results suggested that the water extract of A. lancea rhizomes, used in combination with TP, has a potential in reducing TP-induced toxicity and enhancing its anti-inflammatory effects.
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Índice:
WPRIM
Assunto principal:
Patologia
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Farmacologia
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Fenantrenos
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Plantas Medicinais
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Água
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Extratos Vegetais
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Química
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Indução Enzimática
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Regulação da Expressão Gênica
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Sistema Enzimático do Citocromo P-450
Limite:
Animals
Idioma:
En
Revista:
Chinese Journal of Natural Medicines (English Ed.)
Ano de publicação:
2017
Tipo de documento:
Article