A new saikogenin from the roots of Bupleurum bicaule / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 305-308, 2014.
Article
em En
| WPRIM
| ID: wpr-812259
Biblioteca responsável:
WPRO
ABSTRACT
AIM@#To study the chemical constituents from the roots of Buleurum bicaule Helm (Apiaceae).@*METHOD@#Silica gel, Sephadex LH-20, MPLC Rp-C18 column chromatography, and HPLC were used for isolation of compounds. The structures were elucidated on the basis of 1D- and 2D-NMR technology and HRESI-MS. Compounds were evaluated in vitro for their inhibitory ability against the proliferation of rat mesangial cells by the MTT method.@*RESULTS@#Twelve compounds were isolated, and their structures were identified on the basis of their spectroscopic and physico-chemical properties as 13, 28-epoxy-olean-11-en-3-one (1), saikogenin E (2), saikogenin G (3), 11α-methoxy-3β, 16β, 23, 28-tetrahydroxyolean-12-ene (4), saikogenin D (5), prosaikogenin F (6), prosaikogenin A (7), prosaikogenin G (8), prosaikogenin D (9), laccaic acid (10b), methyl gallate (11), and ethyl gallate (12). Compounds 1, 2, 7, 8, and 10 were observed to have inhibitory activity against mesangial cell proliferationin to different degrees.@*CONCLUSION@#Compound 1, 8, and 10 exhibit significant inhibitory effects on rat mesangial cell proliferation induced by Ang II.
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Assunto principal:
Farmacologia
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Triterpenos
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Medicamentos de Ervas Chinesas
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Estrutura Molecular
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Linhagem Celular
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Química
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Raízes de Plantas
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Bupleurum
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Proliferação de Células
Limite:
Animals
Idioma:
En
Revista:
Chinese Journal of Natural Medicines (English Ed.)
Ano de publicação:
2014
Tipo de documento:
Article