Scopariusols L-T, nine new ent-kaurane diterpenoids isolated from Isodon scoparius / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 456-464, 2018.
Article
em En
| WPRIM
| ID: wpr-812385
Biblioteca responsável:
WPRO
ABSTRACT
Nine new ent-kaurane diterpenoids, named scopariusols L-T (1-9), were isolated from the aerial parts of Isodon scoparius. Their structures were characterized mainly by analyzing the NMR and HR-ESI-MS data, and the absolute configuration of 1 was determined by single-crystal X-ray diffraction. Compound 1 was active against five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW-480), and it also inhibited NO production in LPS-stimulated RAW264.7 cells, with an IC value of 0.6 μmol·L.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Farmacologia
/
Ensaios de Seleção de Medicamentos Antitumorais
/
Medicamentos de Ervas Chinesas
/
Estrutura Molecular
/
Química
/
Lipopolissacarídeos
/
Cristalografia por Raios X
/
Células HL-60
/
Ressonância Magnética Nuclear Biomolecular
/
Isodon
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Chinese Journal of Natural Medicines (English Ed.)
Ano de publicação:
2018
Tipo de documento:
Article