The spectrum-effect relationship-a rational approach to screening effective compounds, reflecting the internal quality of Chinese herbal medicine / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 177-184, 2016.
Article
em En
| WPRIM
| ID: wpr-812438
Biblioteca responsável:
WPRO
ABSTRACT
Since the chromatographic fingerprint was introduced, it has been accepted by many countries to assess the quality and authenticity of Chinese herbal medicine (CHM). However, solely using the chromatographic fingerprint to assay numerous chemicals is not suitable for the assessment of the whole internal quality and pharmacodynamics of CHM. Consequently, it is necessary to develop a rational approach to connecting the chromatographic fingerprint with effective components to assess the internal quality of CHM. For this purpose, a spectrum-effect relationship theory was proposed and accepted as a new method for the assessment of CHM because of its potential use to screen effective components from CHM. In this paper, we systematically reviewed the application of the spectrum-effect relationship theory in the research of CHM, including research mentality, different chromatographic analysis techniques, data processing technologies, and structure determination.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Controle de Qualidade
/
Medicamentos de Ervas Chinesas
/
Farmacocinética
/
Química
/
Modelos Estatísticos
/
Cromatografia
/
Avaliação Pré-Clínica de Medicamentos
/
Métodos
Tipo de estudo:
Diagnostic_studies
/
Risk_factors_studies
/
Screening_studies
Idioma:
En
Revista:
Chinese Journal of Natural Medicines (English Ed.)
Ano de publicação:
2016
Tipo de documento:
Article