Isolation and identification of two new compounds from marine-derived fungus Acremonium fusidioides RZ01 / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 934-938, 2016.
Article
em En
| WPRIM
| ID: wpr-812538
Biblioteca responsável:
WPRO
ABSTRACT
Two new compounds, (22E)-25-carboxy-8β,14β-epoxy-4α,5α-dihydroxyergosta-2,22-dien-7-one (1) and fusidione (3), along with two known compounds, 5α,8α-epidioxy ergosta-6,22-diene-3β-ol (2) and microperfuranone (4), were isolated from the fermentation products of the marine-sourced fungus Acremonium fusidioides RZ01. The structures of compounds 1 and 3 were elucidated by extensive spectroscopic methods, especially 2D NMR, and their absolute configurations were suggested on the basis of the circular dichroism spectral analysis and the NOESY data. Both new compounds showed inhibitory activity against HL-60 cells with IC values being16.6 and 44.9 μmol·L, respectively.
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Texto completo:
1
Índice:
WPRIM
Assunto principal:
Farmacologia
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Água do Mar
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Acremonium
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Espectroscopia de Ressonância Magnética
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Estrutura Molecular
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Química
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Classificação
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Células HL-60
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Proliferação de Células
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Fermentação
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
Idioma:
En
Revista:
Chinese Journal of Natural Medicines (English Ed.)
Ano de publicação:
2016
Tipo de documento:
Article