Diversity synthesis of tetrahydroprotoberberines glycosides by combined chemical and microbial catalysis / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 783-788, 2016.
Article
em En
| WPRIM
| ID: wpr-812557
Biblioteca responsável:
WPRO
ABSTRACT
The present study was designed to construct the structurally diverse library of tetrahydroprotoberberines (THPBs) by combining the methods of chemical nonselective demethylation and microbial glycosylation. HPLC-MS/MS analyses tentatively identified 12 de-methylated and 9 glycosylated derivates of THPBs and 5 rarely oxidized glycosides of THPBs in the library. Through this effort, we achieved not only a variety of the THPBs and their glycosides but also tested the catalytic characteristics and capabilities of G. deliquescens NRRL 1086.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Alcaloides de Berberina
/
Glicosilação
/
Biotransformação
/
Estrutura Molecular
/
Catálise
/
Química
/
Gliocladium
/
Glicosídeos
/
Metabolismo
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
Chinese Journal of Natural Medicines (English Ed.)
Ano de publicação:
2016
Tipo de documento:
Article