Value of sperm acrosin activity detection in selecting the method of assisted reproduction for patients with unexplained infertility / 中华男科学杂志
National Journal of Andrology
; (12): 152-156, 2017.
Article
em Zh
| WPRIM
| ID: wpr-812794
Biblioteca responsável:
WPRO
ABSTRACT
Objective@#To investigate the clinical significance of sperm acrosin activity detection in selecting the method of assisted reproduction for patients with unexplained infertility (UI).@*METHODS@#This retrospective study included 49 UI couples treated by IVFET (49 cycles) after three failures in intrauterine insemination (IUI) and another 95 couples with uterine tube obstruction (UTO) treated by IVF (131 cycles). We analyzed the laboratory data, clinical outcomes and sperm acrosin activity in the two groups of patients. According to the level of sperm acrosin activity of the males, we further divided the UI patients into two subgroups, a 0.05). The sperm acrosin activity was remarkably lower in the UI than in the UTO patients (36.03 vs 61.98 IU/106, P < 0.01), and so was the fertilization rate in the < 36 IU/106 than in the ≥36 IU/106 sperm subgroup (47.7% vs 80.3%, P < 0.01).@*CONCLUSIONS@#The low fertilization rate caused by decreased sperm acrosin activity may be the main cause of infertility and the potential factor of UI. When sperm acrosin activity is < 36 IU/106 sperm, IVF plus shortterm fertilization by remedial ICSI should be preferred to IUI.
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Texto completo:
1
Índice:
WPRIM
Assunto principal:
Implantação do Embrião
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Reprodução
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Espermatozoides
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Acrosina
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Fertilização in vitro
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Estudos Retrospectivos
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Taxa de Gravidez
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Injeções de Esperma Intracitoplásmicas
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Tubas Uterinas
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Infertilidade Feminina
Tipo de estudo:
Diagnostic_studies
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Observational_studies
Limite:
Female
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Humans
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Male
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Pregnancy
Idioma:
Zh
Revista:
National Journal of Andrology
Ano de publicação:
2017
Tipo de documento:
Article