Experimental study of acute lung injury induced by glutamate in vivo / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
; (12): 78-81, 2007.
Article
em Zh
| WPRIM
| ID: wpr-813933
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE@#To investigate the possible injury induced by glutamate in the lung.@*METHODS@#The lung wet weight/body weight (LW/BW), lung wet/dry weight (W/D), the content of cells and the total protein (TP) in bronchoalveolar lavage fluid (BALF) were determined together with the micromorphology observation.@*RESULTS@#(1) The LW/BW, W/D, the content of white blood cells, red blood cells and TP in BALF increased in a dose dependent manner 2 hours after the administration of the glutamate (0.50 - 0.75 g/kg). (2) Examination of histological sections showed the presence of lung inflammation charactered by neutrophils recruitment 2 hours after the glutamate administration. (3) The increase of W/D caused by glutamate (0.50 g/kg) was nearly abolished by pre-treatment with MK801 (a specific blocker of NMDA receptor, 0.1 mg/kg) for 30 minutes (P<0.05).@*CONCLUSION@#Glutamate can cause the acute lung injury through the activation of NMDA receptor in vivo.
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Índice:
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Assunto principal:
Farmacologia
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Líquido da Lavagem Broncoalveolar
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Doença Aguda
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Maleato de Dizocilpina
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Receptores de N-Metil-D-Aspartato
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Ácido Glutâmico
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Biologia Celular
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Contagem de Eritrócitos
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Toxicidade
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Contagem de Leucócitos
Limite:
Animals
Idioma:
Zh
Revista:
Journal of Central South University(Medical Sciences)
Ano de publicação:
2007
Tipo de documento:
Article