Effect of extracts from Radix Trichosanthis on the expression of HBsAg and HBeAg in HepG2.2.15 cells / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
; (12): 38-41, 2012.
Article
em Zh
| WPRIM
| ID: wpr-814604
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE@#To investigate the effect of extracts with water and alcohol from Radix Trichosanthis on the cell survival and the expression of hepatitis B surface antigen (HBsAg) and hepatitis B e-antigen (HBeAg) in HepG2.2.15 cell supernatant.@*METHODS@#The cell survival rate of HepG2.2.15 cells was detected by MTT assay. The HBsAg and HBeAg in HepG 2.2.15 cell supernatant were evaluated by enzyme linked immunosorbent assay.@*RESULTS@#The water and alcohol soluble extracts from Radix Trichosanthis significantly inhibited the levels of HBsAg and HBeAg in HepG2.2.15 cells in a time-and-concentration-dependent manner. However, the therapeutic index of extracts with water from Radix Trichosanthis was better than that in the alcohol group.@*CONCLUSION@#The activity of water-soluble extract from Radix Trichosanthis is stronger on anti-hepatitis B virus than that of the alcohol-soluble extract.
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Antivirais
/
Farmacologia
/
Medicamentos de Ervas Chinesas
/
Vírus da Hepatite B
/
Classificação
/
Células Hep G2
/
Antígenos E da Hepatite B
/
Antígenos de Superfície da Hepatite B
Limite:
Humans
Idioma:
Zh
Revista:
Journal of Central South University(Medical Sciences)
Ano de publicação:
2012
Tipo de documento:
Article