Meta analysis of correlation of angiotensin-converting enzyme gene deletion/insertion polymorphism and risk of pregnancy-induced hypertension in Chinese women / 中南大学学报(医学版)

ABSTRACT

OBJECTIVE@#To investigate the association of the polymorphism of angiotensin-converting enzyme (ACE) gene and pregnancy-induced hypertension (PIH) in Chinese Women.@*METHODS@#We systematically searched CNKI, Wanfang database, VIP and PubMed from database construction to March 2012 to collect case-control studies. Stata 11.0 was used for meta analysis after evaluating the quality of studies and collecting the data. The association was assessed by odds ratio (OR) with 95% confidence intervals (CIs). Publication bias was analyzed by Begg's funnel plot and Egger's regression test.@*RESULTS@#We identified 11 case-control studies on association between ACE gene polymorphism and PIH, which included 806 PIH patients and 900 controls. Overall, significant association was found between ACE gene polymorphism and PIH risk [for D vs I OR=2.73, 95% CI (1.64, 4.24), P<0.001; for DD+DI vs II OR=3.11, 95% CI (1.98, 4.90), P<0.001; for DD vs II OR=5.00, 95% CI (2.30,10.88), P<0.001; for DI vs II OR=1.97, 95% CI(1.53, 2.53), P<0.001].@*CONCLUSION@#Chinese women with D allele gene deletion have a higher risk of suffering pregnancy induced hypertension syndrome.