Effect and mechanism of fluorofenidone on organ fibrosis / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
; (12): 208-213, 2015.
Article
em Zh
| WPRIM
| ID: wpr-815192
Biblioteca responsável:
WPRO
ABSTRACT
Fibrosis can occur in different organs with high incidence rate and great danger. It still lacks effective drugs for prevention of fibrosis. Fluorofenidone is a newly developed drug with anti-fibrotic activity, which provides a new hope for treating the progressive fibrotic diseases. Recent studies have shown that fluorofenidone is a multifunctional small molecule with anti-inflammatory, antioxidative and anti-apoptotic eff ects. It can inhibit the activation and proliferation of myofibroblasts, promote the degradation of extracellular matrix and regulate the cellular signal transmission. Fluorofenidone can be applied to attenuate the progression of renal, hepatic and pulmonary fibrosis.
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Patologia
/
Farmacologia
/
Fibrose Pulmonar
/
Piridonas
/
Fibrose
/
Transdução de Sinais
/
Apoptose
/
Matriz Extracelular
/
Rim
/
Cirrose Hepática
Limite:
Humans
Idioma:
Zh
Revista:
Journal of Central South University(Medical Sciences)
Ano de publicação:
2015
Tipo de documento:
Article