Expression of PI3-K, PKB and GSK-3 β in the skeletal muscle tissue of gestational diabetes mellitus
Asian Pacific Journal of Tropical Medicine
; (12): 309-312, 2014.
Article
em En
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| ID: wpr-819681
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE@#To analyze the expression of phosphatidylinositol 3 kinase (PI3-K), protein kinase B (PKB) and glycogen synthase kinase 3 beta (GSK-3 β) in skeletal muscle tissue of gestational diabetes mellitus (GDM).@*METHODS@#A total of 90 cases of pregnant women were divided into observation group and control group according to the occurrence of GDM with 45 cases in either, and the expression of PI3-K, PKB, GSK-3 β mRNA expression in skeletal muscle tissue was compared between two groups.@*RESULTS@#The total PI3-K p85 protein was significantly higher in the observation group compared with the control group, the activity of PI3-K was lower than that of the latter; The total PKB, GSK-3 β protein in skeletal tissue had no significant difference between two groups, while the serine phosphorylation levels of PKB and GSK-3β were significantly lower in observation group compared with the control group.@*CONCLUSIONS@#The downregulation of PI3-K, PKB and GSK-3βin skeletal tissue of GDM caused by phosphorylation dysfunction of signaling molecules is the reason for insulin resistance and transporter function decline which lead to GDM.
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Assunto principal:
Imuno-Histoquímica
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Química
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Estudos de Coortes
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Diabetes Gestacional
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Músculo Esquelético
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Quinase 3 da Glicogênio Sintase
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Proteínas Proto-Oncogênicas c-akt
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Fosfatidilinositol 3-Quinase
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Glicogênio Sintase Quinase 3 beta
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Metabolismo
Tipo de estudo:
Etiology_studies
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Incidence_studies
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Observational_studies
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Risk_factors_studies
Limite:
Adult
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Female
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Humans
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Pregnancy
Idioma:
En
Revista:
Asian Pacific Journal of Tropical Medicine
Ano de publicação:
2014
Tipo de documento:
Article