Preliminary research of Xiaozhong decoction combined with Conbercept on visual function of diabetic macular edema / 国际眼科杂志(Guoji Yanke Zazhi)
International Eye Science
; (12): 1594-1597, 2020.
Article
em Zh
| WPRIM
| ID: wpr-823398
Biblioteca responsável:
WPRO
ABSTRACT
@#AIM:
To preliminary evaluate retinal sensitivity and the fixation alterations in patients with diabetic macular edema(DME)under Xiaozhong decoction combined intravitreal conbercept therapy. <p>METHODS:
The 40 patients with DME were randomly divided into two groups. Treatment group 20 patients(20 eyes), Xiaozhong decoction combined with conbercept group and treatment group; 20 patients(20 eyes), placebo combined with conbercept group in our hospital from January to October in 2017. The two groups were taken oral Chinese medicinals or placebo for 3mo respectively. BCVA(ETDRS visual acuity test)and CRT(OCT)of the two groups were observed, and the retinal sensitivity and fixation stability(P1, P2)were measured by MAIA microperimetry.<p>RESULTS:
After 3mo of treatment, BCVA of treatment group and control group increased by 4(-1, 11.5)and 0(-4, 0.75)letters compared with baseline(<i>P</i><0.05), and CRT decreased by 123.5±42.61 and 18.1±12.84μm respectively(<i>P</i><0.05). The retinal sensitivity increased slightly after treatment in the two groups, but there was no significant difference between the two groups and over the course of treatment in control group(<i>P</i>>0.05). The sensitivity of retina in treatment group was the highest(20.11±4.98dB)at 2mo. P1 and P2 in the two groups increased significantly after treatment. The increase of P1 in the treatment group was significantly higher than that in the control group at 2mo(<i>P</i><0.05). But there was no difference in the increase of P2 between the two groups after treatment(<i>P</i>>0.05).<p>CONCLUSION:
Intravitreal conbercept could improve the fixation stability in DME patients, combined with Xiaozhong decoction was conducive to maintain fixation stability.
Texto completo:
1
Índice:
WPRIM
Tipo de estudo:
Clinical_trials
Idioma:
Zh
Revista:
International Eye Science
Ano de publicação:
2020
Tipo de documento:
Article