Analysis of risk factors for post-transplant diabetes mellitus in patients with renal transplants / 中华内分泌外科杂志

ABSTRACT

Objective To investigate the incidence and risk factors contributing to post-transplant dia-betes mellitus (PTDM) in kidney transplant recipients within one year post-transplantation. Methods A total of 293 non-diabetic kidney transplant recipients were retrospectively analyzed. Patients were divided into non-PTDM group and PTDM group according to the diagnostic criteria of diabetes mellitus. The incidence of PTDM was cal-culated and the potential risk factors of PTDM were analyzed by univariate and multivariate Logistic regression analysis. Results Among the 293 non-diabetic patients, 36 patients developed PTDM within 1 year, with an in cidence of 12.3％. Multivariate Logistic analysis showed that age (OR 1.055, 95％ CI 1.014-1.098, P=0.009), body mass index [odd ratio (OR) 1.231, 95％ confidence interval (CI) 1.084-1.398, P=0.001], polycystic kidney as the primary disease (OR 1.508, 95％ CI 1.006-2.262, P=0.047), 2-hour postprandial blood glucose (OR 1.186, 95％CI 1.04-1.53, P=0.011), HbA1c (OR 1.732, 95％ CI 1.075-3.428, P=0.015) and 1-hour postprandial blood C-pep-tide (OR 0.869, 95％ CI 0.804-0.939, P=0.001) were independent risk factors for PTDM in kidney transplant re-cipients within 1-year post-transplantation. Conclusion Patients with older age, obesity, polycystic kidney as the primary disease, higher level of HbA1c and 2-hour postprandial blood glucose, and lower level of 1-hour post-prandial blood C-peptide may have higher risk of developing PTDM.