Research progress on mechanism of active ingredients in traditional Chinese medicine for gastric cancer / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 3584-3593, 2020.
Article
em Zh
| WPRIM
| ID: wpr-828409
Biblioteca responsável:
WPRO
ABSTRACT
Gastric cancer is a disease with high mortality, which threatens the health of people for a long time. At present, the main treatment methods are surgery and chemotherapy, but these methods have great harm to the human body. However, it is found that the active ingredients of traditional Chinese medicine have an obvious therapeutic effect in the adjuvant treatment of the tumor. Therefore, the active ingredients of traditional Chinese medicine have become a research hotspot in the anti-tumor field. In recent years, many related researchers have been particularly active in studying the in vitro activity and mechanism of active ingredients of traditional Chinese medicine on human gastric cancer cells. In this paper, the Chinese herbal medicine extracts, polysaccharides, alkaloids, saponins, flavones, terpenes, quinones, volatile oils, esters, phenols, protein components and other active ingredients of Chinese medicine were used as the starting points to investigate the anti-gastric cancer mechanism, such as inhibiting cell proliferation and inducing apoptosis of cancer cells, inhibiting cell invasion and migration; inhibiting over-expression of vascular endothelial growth factor(VEGF); interfering with cell mitosis; and regulating cell signaling pathways. Their in vitro inhibitory activity and mechanism for gastric cancer cells were described in this study, providing a theoretical reference for the development and application of anti-gastric cancer drugs.
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Texto completo:
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Índice:
WPRIM
Assunto principal:
Saponinas
/
Neoplasias Gástricas
/
Medicamentos de Ervas Chinesas
/
Fator A de Crescimento do Endotélio Vascular
/
Medicina Tradicional Chinesa
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2020
Tipo de documento:
Article