A human circulating immune cell landscape in aging and COVID-19
Protein & Cell
; (12): 740-770, 2020.
Article
em En
| WPRIM
| ID: wpr-828746
Biblioteca responsável:
WPRO
ABSTRACT
Age-associated changes in immune cells have been linked to an increased risk for infection. However, a global and detailed characterization of the changes that human circulating immune cells undergo with age is lacking. Here, we combined scRNA-seq, mass cytometry and scATAC-seq to compare immune cell types in peripheral blood collected from young and old subjects and patients with COVID-19. We found that the immune cell landscape was reprogrammed with age and was characterized by T cell polarization from naive and memory cells to effector, cytotoxic, exhausted and regulatory cells, along with increased late natural killer cells, age-associated B cells, inflammatory monocytes and age-associated dendritic cells. In addition, the expression of genes, which were implicated in coronavirus susceptibility, was upregulated in a cell subtype-specific manner with age. Notably, COVID-19 promoted age-induced immune cell polarization and gene expression related to inflammation and cellular senescence. Therefore, these findings suggest that a dysregulated immune system and increased gene expression associated with SARS-CoV-2 susceptibility may at least partially account for COVID-19 vulnerability in the elderly.
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Texto completo:
1
Índice:
WPRIM
Assunto principal:
Pneumonia Viral
/
Espectrometria de Massas
/
Envelhecimento
/
Rearranjo Gênico
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Linfócitos T CD4-Positivos
/
Citocinas
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Análise de Sequência de RNA
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Infecções por Coronavirus
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Regulação da Expressão Gênica no Desenvolvimento
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Linhagem da Célula
Tipo de estudo:
Prognostic_studies
Limite:
Adult
/
Aged
/
Aged80
/
Humans
Idioma:
En
Revista:
Protein & Cell
Ano de publicação:
2020
Tipo de documento:
Article