Sebaceous Carcinoma Coexisting with Squamous Cell Carcinoma in Situ: A Case Report / 대한피부과학회지

ABSTRACT

An 80-year-old woman presented with a yellowish to erythematous plaque that persisted on her left temple for several years. Histopathologic examination revealed a large area of atypical squamous cell infiltration into the epidermis and dermis and a small area of neoplastic basaloid and clear cell proliferation with nuclear atypia in the central portion of the lesion. Immunohistochemical staining was positive and negative for epithelial membrane antigen and cytokeratin 7, respectively, in both the squamous cell and central clear cell infiltration areas. The patient was diagnosed with sebaceous carcinoma associated with squamous cell carcinoma in situ and underwent surgical excision. There have been several reports of sebaceous carcinoma with coinciding tumors in the same lesion, including nevus sebaceous and actinic keratosis. Here, we report a case of sebaceous carcinoma with coexisting squamous cell carcinoma in situ in a patient with a previous history of actinic keratosis in the temple area.