Collateral Ventilation Quantification Using Xenon-Enhanced Dynamic Dual-Energy CT: Differences between Canine and Swine Models of Bronchial Occlusion
Korean Journal of Radiology
; : 648-656, 2015.
Article
em En
| WPRIM
| ID: wpr-83659
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WPRO
ABSTRACT
OBJECTIVE:
The aim of this study was to evaluate whether the difference in the degree of collateral ventilation between canine and swine models of bronchial obstruction could be detected by using xenon-enhanced dynamic dual-energy CT. MATERIALS ANDMETHODS:
Eight mongrel dogs and six pigs underwent dynamic dual-energy scanning of 64-slice dual-source CT at 12-second interval for 2-minute wash-in period (60% xenon) and at 24-second interval for 3-minute wash-out period with segmental bronchus occluded. Ventilation parameters of magnitude (A value), maximal slope, velocity (K value), and time-to-peak (TTP) enhancement were calculated from dynamic xenon maps using exponential function of Kety model.RESULTS:
A larger difference in A value between parenchyma was observed in pigs than in dogs (absolute difference, -33.0 +/- 5.0 Hounsfield units [HU] vs. -2.8 +/- 7.1 HU, p = 0.001; normalized percentage difference, -79.8 +/- 1.8% vs. -5.4 +/- 16.4%, p = 0.0007). Mean maximal slopes in both periods in the occluded parenchyma only decreased in pigs (all p < 0.05). K values of both periods were not different (p = 0.892) in dogs. However, a significant (p = 0.027) difference was found in pigs in the wash-in period. TTP was delayed in the occluded parenchyma in pigs (p = 0.013) but not in dogs (p = 0.892).CONCLUSION:
Xenon-ventilation CT allows the quantification of collateral ventilation and detection of differences between canine and swine models of bronchial obstruction.Palavras-chave
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Índice:
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Assunto principal:
Respiração
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Suínos
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Xenônio
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Broncopatias
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Broncografia
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Ventilação Pulmonar
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Tomografia Computadorizada Espiral
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Obstrução das Vias Respiratórias
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Modelos Animais de Doenças
Limite:
Animals
Idioma:
En
Revista:
Korean Journal of Radiology
Ano de publicação:
2015
Tipo de documento:
Article