Effectiveness of premedication and rapid desensitization in hypersensitivity to L-asparaginase
Allergy, Asthma & Respiratory Disease
;
: 288-293, 2015.
Artigo
em Coreano
| WPRIM
| ID: wpr-83769
ABSTRACT
PURPOSE:
L-asparaginase is a crucial chemotherapeutic agent for the treatment of acute lymphoblastic leukemia. However, hypersensitivity to L-asparaginase is common which limits its clinical use.METHODS:
We performed 44 cases of premedication and 3 cases of desensitization in 16 patients with hypersensitivity to L-asparaginase.RESULTS:
With premedication, 33 cases completed L-asparaginase injection with no hypersensitivity reactions. Eleven cases showed mild hypersensitivity reactions, such as urticaria. Desensitization was performed in 3 cases in 2 cases, desensitization was successful, and in 1 case the medication was switched to Erwinia asparaginase.CONCLUSION:
Premedication and desensitization appear to be useful in helping patients receive desired doses of L-asparaginase in pediatric patients with acute lymphoblastic leukemia.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Pré-Medicação
/
Asparaginase
/
Urticária
/
Dessensibilização Imunológica
/
Hipersensibilidade a Drogas
/
Erwinia
/
Leucemia-Linfoma Linfoblástico de Células Precursoras
/
Hipersensibilidade
Limite:
Humanos
Idioma:
Coreano
Revista:
Allergy, Asthma & Respiratory Disease
Ano de publicação:
2015
Tipo de documento:
Artigo
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