Relationship between α-fetoprotein polymorphisms and peripheral α-fetoprotein level in hepatocellular carcinoma patients / 第二军医大学学报

ABSTRACT

Objective: To study the relationship between α-fetoprotein (AFP) polymorphisms and peripheral AFP level in hepatocellular carcinoma (HCC) patients. Methods: Using polymerase chain reaction-ligation detection reaction (PCR-LDR) technique, we determined the polymorphisms of AFP of 335 HCC patients; the serum levels of AFP were also determined. SPSS 13. 0 softwarewas used for statistical analysis. Results: The GG genotype frequency of -205 OG of AFP gene was significantly different between patients with AFP values: ≥20 and T, intron7 A>G, 3′UTR A>G and intron2 A>G, in AFP gene. Conclusion: In HCC patients among Chinese Hnn population, the C allele and CC genotype of -205 C>G polymorphism site in AFP gene is associated with higher AFP values.