Effect of chronic compression injury of trigeminal nerve root on expression of myelin basic protein and P75 in trigeminal ganglion cells / 解剖学报

ABSTRACT

Objective To investigate the effect of the interaction between satellite glial cells and neurons in the trigeminal ganglion of trigeminal neuralgia (TN) rat model. Methods In the TN rat model (n = 24) induced by trigeminal root entry zone chronic compression and sham group (n = 24), immunofluorescence and Western blotting were used to detect the expression of myelin basic protein (MBP), glial fibrillary acidic protein (GFAP) and of P75 neurotrophic factor receptor (P75) in the trigeminal ganglion. Results The expression of P75NTR in TN group was higher than that in the sham operation group, especially on the post-operation day (POD) 7 and 14 (P<0.01). The expression of MBP in the TN group was decreased after operation, which were significant lower than that in the sham operation group on POD 7 and 14 (P<0.05). While the expression of immunoreactive GFAP in the satellite glial cells in the TN group was higher than that in the sham operation group from POD 7 to POD 21 after operation (P<0.01). Conclusion The changes of MBP and P75NTR expression in neurons and the activation of satellite glial cells in trigeminal ganglion of the TN animal model may affect the interaction of neuron-satellite glial cells, which may be involved in the nociceptive information transmission from orofacial area to the central nervous system in the TN rats.