Current status and thinking of small-molecule drug discovery for the treatment of COVID-19 / 国际药学研究杂志
Journal of International Pharmaceutical Research
; (6): 522-528, 2020.
Article
em Zh
| WPRIM
| ID: wpr-845156
Biblioteca responsável:
WPRO
ABSTRACT
The discovery of small-molecule drugs for the treatment of COVID-19 is one of the most concerned research fields in drug discovery. Different kinds of small-molecule drugs approved or being developed are currently under clinical studies for the treatment of COVID-19. At present, the design of most clinical trials for the treatment of COVID-19 is lack of rationality. Moreover, the efficacy of drugs is controversial. High-quality results of clinical research are urgently needed. There is no small-molecule drugs in clinical studies that have specific effects on SARS-CoV-2. To find more drug candidates, artificial intelligence, structure-based drug design and other methods are applied to discover pre-clinical small molecule compounds against important protein targets of SARS-CoV-2 and virus host. Resources should be further integrated to discover drugs with specific effects to treat COVID-19.
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Índice:
WPRIM
Idioma:
Zh
Revista:
Journal of International Pharmaceutical Research
Ano de publicação:
2020
Tipo de documento:
Article