Progress in aldehyde dehydrogenases and pancreatic cancer and pancreatic cancer stem cells / 肿瘤

ABSTRACT

Pancreatic cancer is a kind of malignant tumor with high mortality rate, low diagnostic rate, and poor prognosis in the digestive system. Aldehyde dehydrogenases (ALDHs) were the intracellular nicotinamide adenine dinucleotide phosphate (NADP+)-dependent enzymes, which play an important role in the metabolism of ethanol, Vitamin A, cyclophosphamide, etc. Recent studies have found that ALDHs are involved in the regulation of many cell signaling pathways, and their expressions are related to the metastasis, prognosis, and drug-resistance of malignancies. In addition, ALDHs as common markers in normal stem cells and cancer stem cells, play an important role in the occurrence and development of pancreatic cancer and pancreatic cancer stem cells. This review discusses the expression and regulatory mechanisms of different subtypes of ALDHs family in pancreatic cancer and pancreatic cancer stem cells, and summarizes the mechanism of action of ALDHs-related anti-tumor drugs, in order to provide theoretical basis for the treatment of pancreatic cancer and the development of novel drugs.