Studies on recursive rule of solubility parameter of active fractions in Buyang Huanwu Decoction / 中草药

ABSTRACT

Objective: To take Buyanghuanwu Decoction as a model for exploring the variable rule of solubility parameters for the effective components group (fraction). Methods: To arrange the experiment design by uniform design and central composite plan, to determine the solubility parameter values with the modified inverse gas chromatography (IGC), and to fit the curve equation using SPSS software. Results: The recursive equation for the major active component including astragaloside (X1), ferulic acid (X2), paeoniflorin (X3), and ligustrazine (X4) was Y = -69.016 + 435.277 X1X2 + 336.966 X2X4 + 487.702 X3X4-54.575 X12-59.696 X2X3 (r = 1.000, P < 0.01); The recursive equation for the active part including total glycosides (X1), and total alkaloids (X2), total polysaccharide (X3) was Y = 21.822 + 10.562 X1 + 51.512 X2-37.078 X3 + 163.820 X1X2-155.569 X1X3-506.750 X2X3-9.385 X12 + 19.864 X22 + 413.446 X32 (r = 0.866, P < 0.01). Conclusion: The recursive rule equation has revealed the inevitable connection between the single component of Chinese materia medica and complex system, which could lay the foundation for the further research on the solubility rule of traditional Chinese medicine compound.