Role and mechanism of glucagon-like peptide-1 in drug addiction / 中国药理学通报

ABSTRACT

Glucagon-like peptide-1 (GLP-1) is an incretin which plays a role in regulating glucose hornêbstasis and appetite, involved in the occurrence and development of type 2 diabetes and obesity. GLP-1 plays the role through regulating insulin secretion and activating the GLP-1 receptor (GLP-1R). Recent studies have found the association between GLP-1 and addictive behaviors caused by cocaine, nicotine, alcohol and amphetamine. This article reviews the role and mechanism of GLP-1 in drug addiction.