Advances in research of TLR/MyD88/NF-κB signaling pathway in different diseases / 中国药理学通报

ABSTRACT

Toll-like receptor (TLR)/MyD88/NF-KB signaling pathway is an important pathway in the body's inflammatory system. It is widely distributed in various tissue cells and participates in the regulation and regulation of various diseases, such as autoimmune diseases, inflammatory diseases, and infectious diseases, allergic diseases, etc. The TLR is a transmembrane protein that recognizes multiple types of pathogen-associated molecular patterns (such as lipopolysaccharide, sodium urate crystals, viral double-stranded RNA, etc.), causing an inflammatory immune response in body, and all TLRs are activated. The MyD88-dependent pathway thereby activates NF-κB, which ultimately leads to the release of inflammatory mediators and cytokines and acts as an anti-inflammatory immune regulator. At present, the research on TLR/MyD88/NF-κB signaling pathway is more in-depth, and has witnessed more progress. This article starts with the mechanism of action of TLR/MyD88/NF-κB signaling pathway in body and reviews its regulation in different diseases.