Pharmacokinetic Characteristics of Oral Hydroxysafflor Yellow A in Rats / 中国药学杂志

ABSTRACT

OBJECTIVE: To investigate the linear pharmacokinetics characteristics of hydroxysafflor yellow A (HSYA) in rats at different doses. METHODS: Eighteen male SD rats were randomly divided into three groups. HSYA was administered intragastrically at doses of 30, 60 and 120 mg•kg-1 respectively. The blood samples were collected from rat fundus venous plexus at preset time points. The blood concentration of HSYA was determined by HPLC. The pharmacokinetic characteristics of HSYA in rats were analyzed by descriptive method and confidence interval method. RESULTS: There were no dose dependence of non-atrioventricular and atrioventricular pharmacokinetic parameters clearance (CL), which were about 6 L•h-1•kg-1. The area under concentration-time curve (AUC) and peak concentration (ρmax) were correlated with the dosage of HSYA. CONCLUSION: The pharmacokinetic parameters AUC of HSYA in the dose range of 30-120 mg•kg-1 have linear kinetic characteristics.