The tissues distribution of hypericin in rats / 中国药学杂志

ABSTRACT

OBJECTIVE: To study the tissues distribution of hypericin in rats. METHODS: A single dose of 50 mg·kg-1 hypericin was administered to healthy SD rats via tail vein. The tissues of heart, liver, spleen, lung, kidney, stomaeh and small intestine were acquired at 20, 45 or 90 min after administration. The concentrations of hypericin in tissues samples were determined by HPLC. RESULTS: After a single tail vein dose of 50 mg·kg-1 hypericin in rats, hypericin was mainly distributed in kidney. The concentrations of hypericin in heart was low. CONCLUSION: This present investigation on hypericin tissues distribution provides important information to further study and clinic use of hypericin.