Oral Administration of Cilostazol Increases Ocular Blood Flow in Patients with Diabetic Retinopathy
Korean Journal of Ophthalmology
; : 123-131, 2017.
Article
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| ID: wpr-8631
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ABSTRACT
PURPOSE: To investigate the effect of cilostazol on ocular hemodynamics and to determine whether the administration of cilostazol increases the ocular blood flow in patients with diabetic retinopathy. METHODS: This prospective observational study investigated the effect of orally administered cilostazol on diabetic retinopathy. Before and after administration for 1 week, pulsatile ocular blood flow (POBF) and retrobulbar hemodynamics were measured using a POBF analyzer and transcranial Doppler imaging, respectively. Visual acuity, intraocular pressure, and blood pressure were also evaluated before and after treatment. RESULTS: Twenty-five eyes of 25 patients were included in this study. POBF increased significantly (16.8 ± 4.6 µL/sec vs. 19.6 ± 6.2 µL/sec, p < 0.001) after administration of cilostazol, while no significant change was identified in visual acuity, intraocular pressure, and blood pressure. Mean flow velocity in the ophthalmic artery as measured with transcranial Doppler imaging also increased significantly after medication (23.5 ± 5.6 cm/sec vs. 26.0 ± 6.9 cm/sec, p = 0.001). The change in POBF directly correlated with the change in mean flow velocity (r = 0.419, p = 0.007). CONCLUSIONS: Cilostazol was effective in increasing ocular blood flow in patients with diabetic retinopathy, possibly by modulating retrobulbar circulation.
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Assunto principal:
Artéria Oftálmica
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Velocidade do Fluxo Sanguíneo
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Pressão Sanguínea
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Fluxo Pulsátil
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Acuidade Visual
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Administração Oral
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Estudos Prospectivos
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Retinopatia Diabética
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Estudo Observacional
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Hemodinâmica
Tipo de estudo:
Observational_studies
Limite:
Humans
Idioma:
En
Revista:
Korean Journal of Ophthalmology
Ano de publicação:
2017
Tipo de documento:
Article