Research advances in pyroptosis of endothelial cells and related diseases / 国际外科学杂志

ABSTRACT

Structural and functional changes of endothelial cells are the basic pathology of many diseases. Pyroptosis is a kind of newly discovered programmed cell death which causes the formation of large pores in the membrane that drive swelling and membrane rupture. Membrane rupture disperses cytosolic contents which further elicit a systemic inflammatory response. Pyroptosis of endothelial cells make a difference in the occurrence and developement of many diseases, including Atherosclerosis, myocardial ischemia-reperfusion injury, acute lung injury, traumatic brain injury and diabetes. In this article, the progress over the years of the research on the involvement of vascular endothelial cells in the pyroptosis is reviewed.