Research progress in predictive biomarkers related to tumor immunotherapy / 国际肿瘤学杂志
Journal of International Oncology
; (12): 487-491, 2020.
Article
em Zh
| WPRIM
| ID: wpr-863512
Biblioteca responsável:
WPRO
ABSTRACT
Tumor immunotherapy is a treatment method mainly for programmed cell death-1 (PD-1) and its ligand PD-L1. PD-1/PD-L1 inhibitors have obvious clinical benefits and long-lasting responses in a variety of tumors. But overall response rates are still low. Studies show that PD-L1 and tumor mutation burden can predict the effect of immunotherapy. MSI-H/dMMR, TP53 and KRAS mutations are positively correlated with the effect of immunotherapy. While MDM2/4, EGFR, ALK and other genes are negatively correlated with the effect of immunotherapy.
Texto completo:
1
Índice:
WPRIM
Tipo de estudo:
Prognostic_studies
Idioma:
Zh
Revista:
Journal of International Oncology
Ano de publicação:
2020
Tipo de documento:
Article