Recent progress of host susceptibility gene polymorphisms in Isoniazid induced liver injury / 中华实用儿科临床杂志
Chinese Journal of Applied Clinical Pediatrics
; (24): 762-766, 2020.
Article
em Zh
| WPRIM
| ID: wpr-864100
Biblioteca responsável:
WPRO
ABSTRACT
Tuberculosis (TB) is an infectious fatal disease that seriously endangers human health worldwide.Isoniazid (INH) is an important first-line drug for TB, but it can cause serious adverse drug reactions, such as liver injury and even liver failure.At present, it is believed that metabolites of INH, imbalance of oxidative stress responses and immune response disorders are major causes of INH induced liver injury.In addition, involved genes and gene polymorphisms are susceptible to liver injury caused by INH.In this paper, the association of INH induced liver injury with the polymorphisms of genes related to INH metabolizing enzymes, as well as oxidative stress and immune responses are summarized to improve the understanding of INH induced liver injury and provide novel directions for its prevention and treatment.
Texto completo:
1
Índice:
WPRIM
Idioma:
Zh
Revista:
Chinese Journal of Applied Clinical Pediatrics
Ano de publicação:
2020
Tipo de documento:
Article