Analysis of correlation between expression of vascular endothelial growth factor, MMP-2 and MMP-9 and clinical prognosis of patients with hepatocellular carcinoma / 中国基层医药

ABSTRACT

Objective:To investigate the correlation between the expression of vascular endothelial growth factor (VEGF), MMP-2, MMP-9 and the clinicopathology and prognosis of patients with hepatocellular carcinoma (HCC), and to provide evidence for the occurrence and development of HCC.Methods:From April 2015 to March 2016, 95 HCC tissues were resected in Yiwu Central Hospital.Forty-fivenormal liver tissues which were resected due to liver trauma were selected as control group.Immunohistochemical staining was used to detect the expression of VEGF, MMP-2 and MMP-9 in HCC and normal liver tissues, and the correlation between the expression of VEGF, MMP-2, MMP-9 and clinical pathology and prognosis was analyzed.Results:The positive expression rates of VEGF, MMP-2 and MMP-9 in the HCC tissues were significantly higher than those in the normal liver tissues (81.05%, 75.79%, 84.21% vs.42.22%, 33.33%, 48.89%)(χ 2=21.364, 23.397, 19.265, all P<0.05). The positive expression rates of VEGF, MMP-2 and MMP-9 in HCC were significantly increased in patients with poor differentiation, TNM stage Ⅲ-Ⅳ and vascular invasion (all P<0.05). The survival of patients with negative expression of VEGF, MMP-2 and MMP-9 in HCC tissues was significantly better than that of patients with positive expression (log χ 2=3.271, 2.975, 3.065, all P<0.05). Conclusion:The high expression of VEGF, MMP-2 and MMP-9 plays an important role in the growth, invasion and metastasis of HCC tissues.Therefore, VEGF, MMP-2 and MMP-9 can be used as biological indicators of the progression of HCC.