The effect of stimulation of the central thalamus on the expression of α1R in the prefrontal cortex after traumatic brain injury / 中华物理医学与康复杂志
Chinese Journal of Physical Medicine and Rehabilitation
; (12): 865-869, 2020.
Article
em Zh
| WPRIM
| ID: wpr-871231
Biblioteca responsável:
WPRO
ABSTRACT
Objective:
To investigate the effect of stimulation of the central thalamus (CT-DBS) on awakening from coma after traumatic brain injury and the mechanisms involved.Methods:
Forty-five healthy, adult Wistar rats were randomly assigned to either a blank control group, a sham stimulation or a stimulation group, each of 15. CT-DBS was applied in the stimulation group. Behavioral changes were observed, and the content of α1-adrenergic receptor (α1R) in the prefrontal cortex (PFC) was measured using immunofluorescence and western blotting.Results:
The varus reflex was found in all 15 rats in the stimulation group, but in only 8 among the sham stimulation group. The average α1R content in the PFC was significantly higher in the stimulation group than in the sham stimulation group.Conclusions:
CT-DBS can improve the level of consciousness after traumatic brain injury and promote awakening, at least in rats. The mechanisms may be related to the up-regulation of α1R expression in the PFC.
Texto completo:
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Índice:
WPRIM
Idioma:
Zh
Revista:
Chinese Journal of Physical Medicine and Rehabilitation
Ano de publicação:
2020
Tipo de documento:
Article