Research progresses on PGC-1α, a key energy metabolic regulator / 生理学报
Acta Physiologica Sinica
; (6): 804-816, 2020.
Article
em Zh
| WPRIM
| ID: wpr-878228
Biblioteca responsável:
WPRO
ABSTRACT
Disturbance of the energy balance, when the energy intake exceeds its expenditure, is a major risk factor for the development of metabolic syndrome (MS). The peroxisome proliferator activated receptor γ (PPARγ) coactivator-1α (PGC-1α) functions as a key regulator of energy metabolism and has become a hotspot in current researches. PGC-1α sensitively responds to the environmental stimuli and nutrient signals, and further selectively binds to different transcription factors to regulate various physiological processes, including glucose metabolism, lipid metabolism, and circadian clock. In this review, we described the gene and protein structure of PGC-1α, and reviewed its tissue-specific function in the regulation of energy homeostasis in various mammalian metabolic organs, including liver, skeletal muscle and heart, etc. At the meanwhile, we summarized the application of potential small molecule compounds targeting PGC-1α in the treatment of metabolic diseases. This review will provide theoretical basis and potential drug targets for the treatment of metabolic diseases.
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Fatores de Transcrição
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Músculo Esquelético
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Metabolismo Energético
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Metabolismo dos Lipídeos
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Coativador 1-alfa do Receptor gama Ativado por Proliferador de Peroxissomo
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Homeostase
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Fígado
Limite:
Animals
Idioma:
Zh
Revista:
Acta Physiologica Sinica
Ano de publicação:
2020
Tipo de documento:
Article