Research progress of effect of berberine in treatment of ulcerative colitis based on cell signaling pathway / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 33-40, 2021.
Article
em Zh
| WPRIM
| ID: wpr-878907
Biblioteca responsável:
WPRO
ABSTRACT
Berberine is the main extract of Coptis chinensis, and its anti-inflammatory, antioxidant, antibacterial and immunomodulatory effects have been confirmed by modern studies. Ulcerative colitis(UC) is a chronic, idiopathic inflammatory bowel disease with unknown etiology. Its causes involve genetics, intestinal microecology and mucosal immune system disorders. In this paper, literatures on relevant pathways and mechanism of berberine on ulcerative colitis in recent years were consulted and summarized to provide me-thods and ideas for developing berberine in the treatment of UC and exploring the mechanisms. The results showed that berberine protects the intestinal mucosal barrier, restores the body's normal immune response, and improves oxidative stress by regulating multiple signaling pathways, such as JAK-STAT, NK-κB, PI3 K-AKT, MAPK, Nrf2, ERS, and MLCK-MLC, so as to treat UC.
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Texto completo:
1
Índice:
WPRIM
Assunto principal:
Berberina
/
Transdução de Sinais
/
Colite Ulcerativa
/
Colite
/
Mucosa Intestinal
Limite:
Humans
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2021
Tipo de documento:
Article