Research progress on bidirectional effect of microRNA on Alzheimer's disease and intervention with traditional Chinese medicine / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 1743-1751, 2021.
Article
em Zh
| WPRIM
| ID: wpr-879088
Biblioteca responsável:
WPRO
ABSTRACT
Alzheimer's disease(AD) is a chronic progressive neurodegenerative disease with recent memory impairment as the main clinical manifestation and senile plaques and neurofibrillary tangles as the main pathological changes. In recent years, the effect of microRNAs on AD has attracted widespread attention. Patients with AD have abnormal expression of miRNA, which is closed related to regulation of AD pathophysiology-related genes. Therefore, this paper first elaborated neuroprotective and toxic effects of microRNA in AD, and then explored relevant traditional Chinese medicines that can regulate miRNA in the treatment of AD, so as to provide basis for revealing the pathogenesis relationship between miRNA and AD and provide ideas for further development of anti-AD traditional Chinese medicine.
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Texto completo:
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Índice:
WPRIM
Assunto principal:
Doenças Neurodegenerativas
/
MicroRNAs
/
Doença de Alzheimer
/
Medicina Tradicional Chinesa
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2021
Tipo de documento:
Article