Role of ATP6V1H gene in bone metabolism / 中国骨伤
China Journal of Orthopaedics and Traumatology
; (12): 265-268, 2021.
Article
em Zh
| WPRIM
| ID: wpr-879427
Biblioteca responsável:
WPRO
ABSTRACT
Osteoporosis is one of the common clinical orthopedic diseases, which can lead to a variety of complications. There are many pathogenic factors in this disease. The latest research found that ATP6V1H is a new gene leading to the occurrence of osteoporosis, and it is likely to become a new target for the future drug treatment of osteoporosis.This paper introduces the biological structure and characteristics of H subunit, summed up the human body caused by loss of ATP6V1H and animal models such as zebrafish, mice bone loss and osteoporosis symptom such as related research reports of the loss, from osteoclast, osteoblast and marrow stromal cell level and the connection between the various subunits further expounds the H subunit regulate bone dynamic balance of mechanism, to explore ATP6V1H in bone developmentand bone related diseases has laid a solid foundation, also provide new ideas for clinical treatment of osteoporosis.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Osteoblastos
/
Osteoclastos
/
Osteoporose
/
Osso e Ossos
/
Peixe-Zebra
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
Zh
Revista:
China Journal of Orthopaedics and Traumatology
Ano de publicação:
2021
Tipo de documento:
Article