Research Status of New Targets MRD Detection in Acute Myeloid Leukemia Recurrence--Review / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 293-296, 2021.
Article
em Zh
| WPRIM
| ID: wpr-880070
Biblioteca responsável:
WPRO
ABSTRACT
Although most acute myeloid leukemia (AML) patients can achieve complete remission (CR) induced by standardized chemotherapy, but the relapse rate after remission remains high. The key reason is its high heterogeneity in cytogenetics and molecular biology. There are evidences show that minimal residual disease (MRD) is closely associated with disease recurrence, so that, finding specific genetic and molecular biological changes as new targets for MRD detection has become a research hotspot in recent years. In this review the intrinsic relationship between relapse of AML and MRD detection of specific molecular events, the application of these new targets in MRD detection and their targeted therapies according to the latest guidelines, so as to achieve the optimal treatment in CR phase.
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Prognóstico
/
Recidiva
/
Indução de Remissão
/
Leucemia Mieloide Aguda
/
Neoplasia Residual
/
Citometria de Fluxo
Tipo de estudo:
Diagnostic_studies
/
Guideline
/
Prognostic_studies
Limite:
Humans
Idioma:
Zh
Revista:
Journal of Experimental Hematology
Ano de publicação:
2021
Tipo de documento:
Article