Safety of protease inhibitors and Arbidol for SARS-CoV-2 pneumonia in Zhejiang Province, China / 浙江大学学报(英文版)(B辑:生物医学和生物技术)
Journal of Zhejiang University. Science. B
; (12): 948-954, 2020.
Article
em En
| WPRIM
| ID: wpr-880736
Biblioteca responsável:
WPRO
ABSTRACT
The aim of this study was to evaluate the safety of an antiviral regimen of protease inhibitors combined with Arbidol (umifenovir) for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia patients. The genomic sequence of SARS-CoV-2 is highly homologous to that of SARS-CoV (Zhou et al., 2020). Previously published basic and clinical research on anti-SARS-CoV treatment found that lopinavir/ritonavir (LPV/r) could improve the prognosis of SARS patients (Chan et al., 2003; Chu et al., 2004). Darunavir (DRV) is another protease inhibitor that blocks the binding of SARS-CoV-2 to human angiotensin-converting enzyme 2 (Omotuyi et al., 2020). The broad-spectrum antiviral drug Arbidol (umifenovir) also shows in vitro anti-SARS-CoV activity (Khamitov et al., 2008).
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Texto completo:
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Índice:
WPRIM
Assunto principal:
Inibidores de Proteases
/
China
/
Estudos Retrospectivos
/
Ritonavir
/
Combinação de Medicamentos
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Metabolismo dos Lipídeos
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Lopinavir
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Darunavir
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SARS-CoV-2
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COVID-19
Tipo de estudo:
Observational_studies
Limite:
Adult
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Female
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Humans
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Male
País/Região como assunto:
Asia
Idioma:
En
Revista:
Journal of Zhejiang University. Science. B
Ano de publicação:
2020
Tipo de documento:
Article