Arctiin antagonizes triptolide-induced renal toxicity in rats via anti-inflammatory pathway / 南方医科大学学报
Journal of Southern Medical University
; (12): 1399-1405, 2020.
Article
em Zh
| WPRIM
| ID: wpr-880776
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WPRO
ABSTRACT
OBJECTIVE@#To investigate the protective effect of arctiin with anti-inflammatory bioactivity against triptolide-induced nephrotoxicity in rats and explore the underlying mechanism.@*METHODS@#Forty SD rats were divided into 4 groups for gastric lavage of normal saline, arctiin (500 mg/kg), triptolide (500 μg/kg), or both arctiin (500 mg/kg) and triptolide (500 μg/kg). Blood samples were collected for analysis of biochemical renal parameters, and the renal tissues were harvested for determining the kidney index and for pathological evaluation with HE staining. In the @*RESULTS@#In SD rats, arctiin significantly antagonized triptolide-induced elevation of BUN, Scr and kidney index (@*CONCLUSIONS@#Arctiin can protect the kidney from triptolide-induced damages in rats possibly through the anti-inflammatory pathway.
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WPRIM
Assunto principal:
Fenantrenos
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Ratos Sprague-Dawley
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Diterpenos
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Compostos de Epóxi
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Furanos
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Glucosídeos
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Rim
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Anti-Inflamatórios
Limite:
Animals
Idioma:
Zh
Revista:
Journal of Southern Medical University
Ano de publicação:
2020
Tipo de documento:
Article