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Discovery of highly selective and orally available benzimidazole-based phosphodiesterase 10 inhibitors with improved solubility and pharmacokinetic properties for treatment of pulmonary arterial hypertension
Acta Pharmaceutica Sinica B ; (6): 2339-2347, 2020.
Article em En | WPRIM | ID: wpr-881115
Biblioteca responsável: WPRO
ABSTRACT
Optimization efforts were devoted to discover novel PDE10A inhibitors in order to improve solubility and pharmacokinetics properties for a long-term therapy against pulmonary arterial hypertension (PAH) starting from the previously synthesized inhibitor
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Texto completo: 1 Índice: WPRIM Idioma: En Revista: Acta Pharmaceutica Sinica B Ano de publicação: 2020 Tipo de documento: Article
Texto completo: 1 Índice: WPRIM Idioma: En Revista: Acta Pharmaceutica Sinica B Ano de publicação: 2020 Tipo de documento: Article